Health

Study: ADHD Drugs Have Minimal Cardiovascular Side Effects

Published APR 7 2025

Story

Above: Concerta, a medicine used in the treatment of ADHD. Image credit: Jaap Arriens/Contributor/NurPhoto via Getty Images

The Facts

According to a comprehensive analysis of 102 clinical trials involving 22,702 participants published Sunday, ADHD drugs generally have small effects on blood pressure and heart rate — a documented side effect of the treatment — with most medications causing slight increases in cardiovascular parameters.
guardian
EurekAlert!
The study, led by the University of Southampton, encompassed 13,315 children and adolescents and 9,387 adults, with a median follow-up period of seven weeks.
The Lancet
Medicalxpress
In children and adolescents, the mean increase in systolic blood pressure ranged from 1.07 mm Hg with atomoxetine to 1.81 mm Hg with methylphenidate, while pulse rate increases ranged from 2.79 beats per minute (bpm) with viloxazine to 5.58 bpm with atomoxetine.
The Lancet
It found no significant differences between stimulant medications like methylphenidate and non-stimulant treatments regarding their effects on blood pressure and heart rate, challenging previous assumptions about stimulant medications carrying higher cardiovascular risks.
Dailyaus
Southampton
Researchers added that guanfacine was the only medication that showed decreased blood pressure and heart rate. In contrast, other ADHD medications led to small increases in these parameters, highlighting the need for monitoring regardless of medication type.
News
Medicalxpress
The study's findings have prompted researchers to recommend systematic monitoring of blood pressure and heart rate for all patients taking ADHD medications, regardless of whether they are taking stimulants or non-stimulants.
Neuroscience News
Southampton

Sources Split

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CENTER

RIGHT

ESTAB
CRIT

CENTER

PRO
ESTAB

The Spin

Narrative A

The benefits of ADHD drugs significantly outweigh their minimal cardiovascular risks, with clear evidence showing improvements in academic performance, reduced mortality risk, and better quality of life outcomes. These medications serve as cognitive enhancers that improve information processing and reduce impulsivity, making them essential tools for managing ADHD effectively.

guardian

Narrative B

While current data shows small cardiovascular effects, the lack of long-term studies raises concerns about potential risks over extended periods. More detailed guidelines are needed for adjusting or stopping medication when necessary, and the current system for handling increasing ADHD treatment demands is becoming obsolete.

The Lancet